Revisiting propafenone toxicity
نویسندگان
چکیده
منابع مشابه
Revisiting Metal Toxicity in Neurodegenerative Diseases and Stroke: Therapeutic Potential
Excessive accumulation of pro-oxidant metals, observed in affected brain regions, has consistently been implicated as a contributor to the brain pathology including neurodegenerative diseases and acute injuries such as stroke. Furthermore, the potential interactions between metal toxicity and other commonly associated etiological factors, such as misfolding/aggregation of amyloidogenic proteins...
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The objective of this randomized, double-blind, placebo-controlled clinical trial was to test the efficacy and safety of a new sustained-release preparation of the antiarrhythmic drug propafenone (propafenone SR) in reducing the frequency of symptomatic arrhythmia recurrences in patients with atrial fibrillation (AF). Patients with a history of symptomatic AF who were in sinus rhythm were rando...
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(Chest 1990; 98:434-41) P ropafenone is a new class IC antiarrhythmic agent that has just l)een released in the United States for use in treatment o)f malignant ventricular arrhythmias (Rythmol, Knoll Pharmaceuticals, Whippany, New Jersey). It was first marketed in Europe in 1977, and has gained wide acceptance there and in Canada for the treatment of various types of ventricular and supraventr...
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We determined the efficacy, pharmacokinetics, and plasma concentration-response relationships ofpropafenone, a promising new antiarrhythmic drug. Thirteen patients with frequent and complex ventricular premature beats were studied after receiving four increasing doses, during drug washout and during a randomized double-blind placebo-controlled trial, to evaluate the optimal dose in each patient...
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ژورنال
عنوان ژورنال: BMJ Case Reports
سال: 2017
ISSN: 1757-790X
DOI: 10.1136/bcr-2017-219270